Oral Liquid Grinding Homogenizer

Oral liquids offer advantages such as small dosage, rapid absorption, stable quality, convenience in carrying and administration, and ease of storage, making them particularly suitable for industrial production. Some varieties are suitable for emergency treatments in traditional Chinese medicine, such as Sini Tang Oral Liquid and Yin Huang Oral Liquid. Therefore, in recent years, tablets, Chinese medicine mixtures, injections, and other formulations have often been modified into oral liquids, making them one of the fastest-growing dosage forms in pharmaceutical preparations. However, the production equipment and process conditions for oral liquids require higher standards, resulting in relatively high costs.

Since oral liquids are administered orally, the requirements for them are very high, with quality and safety being the core concerns. The quality of oral liquids depends on particle size refinement. The smaller the particle size of the materials, the more stable the product and the less likely it is to precipitate. Moreover, the human body can absorb it more easily. The traditional production equipment for oral liquids is a disperser, typically operating at 3000 rpm. With the continuous improvement of the pharmaceutical industry and the increasing emphasis on hygiene and safety, ordinary dispersers can no longer meet industry requirements in terms of effectiveness and safety.

GRS2000 Oral Liquid Grinding Homogenizer, as a device used for mixing and dispersion processes, features continuous operation and is also known as a continuous ultra-high-speed mixing disperser. It can effectively meet the demands of large-scale continuous production and offers many advantages compared to traditional batch dispersers:

(1) Higher dispersion efficiency. Batch dispersers often require pre-mixing before dispersion to achieve better mixing and dispersion effects, which takes more time and results in lower output, making them suitable for discontinuous production or small-scale output. In contrast, continuous dispersers allow direct feeding, achieving the required particle size of the mixture in a shorter time with higher output and efficiency, making them suitable for continuous production and large-scale output.

(2) Better dispersion effect. Batch dispersers are installed in tanks, with a loose distance between the material and the dispersion head. During operation, they rely on strong suction to force the material into the dispersion head, but some material may still escape during the dispersion process. The particle size distribution after mixing and dispersion is relatively wide. Additionally, batch dispersers generally feature only a single-layer dispersion head structure, which cannot achieve sufficiently small particle size requirements. In contrast, continuous dispersers have a smaller internal design space in the dispersion chamber.

The dispersion head closely contacts the material, ensuring sufficient shear. The dispersion chamber is designed with a multi-layer stator-rotor engagement structure, optimizing the coarse and fine tooth profiles, resulting in a narrower particle size distribution after mixing and dispersion and higher efficiency.

(3) Better technical performance indicators. As shown in Table 1, the GRS2000 series products have significant advantages in speed compared to batch products under the same motor conditions, offering relatively energy-efficient and high-performance benefits. They can process more qualified material products in a shorter time, helping large-scale production enterprises reduce costs during the production process.

The GRS2000 Grinding Homogenizer is specifically designed by SGN Company for the mixing and dispersion processes in the pharmaceutical industry, adhering to management standards such as GMP. Therefore, it was designed with FDA and GHGDG standards in mind, meeting the requirements of the pharmaceutical industry. The equipment is made of SS316 steel or Hastelloy, offering corrosion and wear resistance, minimizing physical and chemical reactions with materials that could lead to contamination. At the same time, the equipment design is flexible. Depending on the needs of different enterprises, adapters can be added to the motor to suit production requirements; explosion-proof motors can be installed to meet the requirements of explosion-proof workshops; different modules can be replaced, and the combination of dispersion heads can be used to meet different particle size distribution requirements; the machine's position can be adjusted according to the actual production environment and layout of the enterprise. For example, if the enterprise's feed port is low, the equipment can be changed from vertical to horizontal to meet the actual production conditions.

The Oral Liquid Grinding Homogenizer, pharmaceutical emulsions disperser, GRS2000, demonstrates significant advantages in the production of vaccines, fat emulsions, and serum. Its design meets the requirements of the pharmaceutical industry while satisfying the particle size requirements of different products, showing great potential for application in the dispersion and mixing processes of pharmaceuticals.